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Amorphous Nanosuspensions Aggregated from Paclitaxel–Hemoglobulin Complexes with Enhanced Cytotoxicity

Amorphous nanosuspensions (ANSs) enable rapid release and improved delivery of a poorly water-soluble drug; however, their preparation is challenging. Here, using hemoglobin (Hb) as a carrier, ANSs aggregated from paclitaxel (PTX)–Hb complexes were prepared to improve delivery of the hydrophobic ant...

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Detalles Bibliográficos
Autores principales: Qin, Chao, Xin, Xiaofei, Pei, Xue, Yin, Lifang, He, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161098/
https://www.ncbi.nlm.nih.gov/pubmed/30011808
http://dx.doi.org/10.3390/pharmaceutics10030092