Stable Isotope-Resolved Metabolomics Shows Metabolic Resistance to Anti-Cancer Selenite in 3D Spheroids versus 2D Cell Cultures

Conventional two-dimensional (2D) cell cultures are grown on rigid plastic substrates with unrealistic concentration gradients of O(2), nutrients, and treatment agents. More importantly, 2D cultures lack cell–cell and cell–extracellular matrix (ECM) interactions, which are critical for regulating ce...

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Detalles Bibliográficos
Autores principales: Fan, Teresa W.-M., El-Amouri, Salim S., Macedo, Jessica K. A., Wang, Qing Jun, Song, Huan, Cassel, Teresa, Lane, Andrew N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161115/
https://www.ncbi.nlm.nih.gov/pubmed/29996515
http://dx.doi.org/10.3390/metabo8030040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161115/
https://www.ncbi.nlm.nih.gov/pubmed/29996515
http://dx.doi.org/10.3390/metabo8030040

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