DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways

Doxorubicin (DOX) is a very potent and effective anticancer agent. However, the effectiveness of DOX in osteosarcoma is usually limited by the acquired drug resistance. Recently, Vitamin D (Vit-D) was shown to suppress the growth of many human cancer cells. Taken together, we synthesized DOX-Vit D b...

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Detalles Bibliográficos
Autores principales: Maayah, Zaid H., Zhang, Ti, Forrest, Marcus Laird, Alrushaid, Samaa, Doschak, Michael R., Davies, Neal M., El-Kadi, Ayman O. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161239/
https://www.ncbi.nlm.nih.gov/pubmed/30181466
http://dx.doi.org/10.3390/pharmaceutics10030144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161239/
https://www.ncbi.nlm.nih.gov/pubmed/30181466
http://dx.doi.org/10.3390/pharmaceutics10030144

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