Cargando…

Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol

Osthenol is a prenylated coumarin isolated from the root of Angelica koreana and Angelica dahurica, and is an O-demethylated metabolite of osthole in vivo. Its various pharmacological effects have been reported previously. The metabolic pathway of osthenol was partially confirmed in rat osthole stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cho, Pil Joung, Paudel, Sanjita, Lee, Doohyun, Jin, Yun Ji, Jo, GeunHyung, Jeong, Tae Cheon, Lee, Sangkyu, Lee, Taeho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161247/ https://www.ncbi.nlm.nih.gov/pubmed/30200214 http://dx.doi.org/10.3390/pharmaceutics10030141

Ejemplares similares

Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation
por: Shrestha, Riya, et al.
Publicado: (2018)

Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators
por: Paudel, Sanjita, et al.
Publicado: (2019)

Selective Inhibition of Bakuchicin Isolated from Psoralea corylifolia on CYP1A in Human Liver Microsomes
por: Kim, Sun Joo, et al.
Publicado: (2016)

Discovery and Validation of a Novel Step Catalyzed by OsF3H in the Flavonoid Biosynthesis Pathway
por: Jan, Rahmatullah, et al.
Publicado: (2021)

Comprehensive Investigation of Stereoselective Food Drug Interaction Potential of Resveratrol on Nine P450 and Six UGT Isoforms in Human Liver Microsomes
por: Ji, Seung-Bae, et al.
Publicado: (2021)

Global Lysine Acetylome Analysis of LPS-Stimulated HepG2 Cells Identified Hyperacetylation of PKM2 as a Metabolic Regulator in Sepsis
por: Na, Ann-Yae, et al.
Publicado: (2021)

Kinetic Characteristics of Curcumin and Germacrone in Rat and Human Liver Microsomes: Involvement of CYP Enzymes
por: Su, Shaofeng, et al.
Publicado: (2022)

In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics
por: Kim, Sin-Eun, et al.
Publicado: (2021)

Metabolism of Diterpenoids Derived from the Bark of Cinnamomum cassia in Human Liver Microsomes
por: Choi, Su Min, et al.
Publicado: (2021)

Inhibition of UGT2B7 Enzyme Activity in Human and Rat Liver Microsomes by Herbal Constituents
por: Abdullah, Nurul Huda, et al.
Publicado: (2018)

The one-step fabrication of porous hASC-laden GelMa constructs using a handheld printing system
por: Jo, SeoYul, et al.
Publicado: (2023)

Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma
por: Lin, P, et al.
Publicado: (2000)

Identification of Histone Lysine Acetoacetylation as a Dynamic Post‐Translational Modification Regulated by HBO1
por: Gao, Yan, et al.
Publicado: (2023)

Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4
por: Liu, Wenqin, et al.
Publicado: (2015)

Bio-printing of aligned GelMa-based cell-laden structure for muscle tissue regeneration
por: Hwangbo, Hanjun, et al.
Publicado: (2021)

Hybrid cell constructs consisting of bioprinted cell‐spheroids
por: Kim, WonJin, et al.
Publicado: (2022)

Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes
por: Lu, Yan, et al.
Publicado: (2017)

Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes
por: Zhan, Yunyun, et al.
Publicado: (2023)

Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound
por: Park, Kyunghye, et al.
Publicado: (2016)

Efficient Syntheses of 1,2,3-Triazoloamide Derivatives Using Solid- and Solution-Phase Synthetic Approaches
por: Lee, Doohyun, et al.
Publicado: (2015)

Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes
por: Bloom, Adam Joseph, et al.
Publicado: (2019)

CYP3A4, CYP2C9 and CYP2B6 expression and ifosfamide turnover in breast cancer tissue microsomes
por: Schmidt, R, et al.
Publicado: (2004)

Strong and Selective Inhibitory Effects of the Biflavonoid Selamariscina A against CYP2C8 and CYP2C9 Enzyme Activities in Human Liver Microsomes
por: Park, So-Young, et al.
Publicado: (2020)

An in vitro model using spheroids-laden nanofibrous structures for attaining high degree of myoblast alignment and differentiation
por: Yeo, Miji, et al.
Publicado: (2021)

Genome-Wide Analysis of UGT Genes in Petunia and Identification of PhUGT51 Involved in the Regulation of Salt Resistance
por: Dong, Lili, et al.
Publicado: (2022)

The reference liver—CYP450 and UGT enzymes in healthy donor and metastatic livers: the impact of genotype
por: Kurzawski, Mateusz, et al.
Publicado: (2021)

Characterization of the Asiatic Acid Glucosyltransferase, UGT73AH1, Involved in Asiaticoside Biosynthesis in Centella asiatica (L.) Urban
por: Kim, Ok Tae, et al.
Publicado: (2017)

Bone tissue engineering supported by bioprinted cell constructs with endothelial cell spheroids
por: Kim, WonJin, et al.
Publicado: (2022)

The Effect of UGT1A9, CYP2B6 and CYP2C9 Genes Polymorphism on Propofol Pharmacokinetics in Children
por: Pavlovic, Dimitrije, et al.
Publicado: (2020)

Pharmacogenetics of CYP2A6, CYP2B6, and UGT2B7 in the Context of HIV Treatments in African Populations
por: Ford, Graeme R., et al.
Publicado: (2022)

Investigation of the Regulatory Effects of Saccharin on Cytochrome P450s in Male ICR Mice
por: Jo, Jun Hyeon, et al.
Publicado: (2017)

Extracellular Vesicles Act as Nano-Transporters of Tyrosine Kinase Inhibitors to Revert Iodine Avidity in Thyroid Cancer
por: Rajendran, Ramya Lakshmi, et al.
Publicado: (2021)

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
por: Kazuki, Yasuhiro, et al.
Publicado: (2019)

Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
por: Yang, Fan, et al.
Publicado: (2023)

Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5
por: Ye, Ling, et al.
Publicado: (2013)

A skeleton muscle model using GelMA-based cell-aligned bioink processed with an electric-field assisted 3D/4D bioprinting
por: Yang, Gi Hoon, et al.
Publicado: (2021)

Cell-Electrospinning and Its Application for Tissue Engineering
por: Hong, Jiyoung, et al.
Publicado: (2019)

Fabrication of Mechanically Reinforced Gelatin/Hydroxyapatite Bio-Composite Scaffolds by Core/Shell Nozzle Printing for Bone Tissue Engineering
por: Kim, Haeri, et al.
Publicado: (2020)

The utility of biomedical scaffolds laden with spheroids in various tissue engineering applications
por: Chae, SooJung, et al.
Publicado: (2021)

Differential Effects of 1α,25-Dihydroxyvitamin D(3) on the Expressions and Functions of Hepatic CYP and UGT Enzymes and Its Pharmacokinetic Consequences In Vivo
por: Doan, Trang Nguyen Kieu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7q9v1sfg4pogmf1vo0aisel8qd