A Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Nimbolide in Mouse Serum: Application to a Preclinical Pharmacokinetics Study

A sensitive and robust liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the determination of nimbolide in mouse serum. Exemestane was used as the internal standard (IS). Here, we employed acetonitrile-based protein precipitation (PPT) for serum sample...

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Detalles Bibliográficos
Autores principales: Wang, Lingzhi, Phan, Do-Dang Khoa, Syn, Nicholas, Xiang, Xiaoqiang, Song, Hongyan, Thuya, Win Lwin, Yang, Shili, Wong, Andrea Li-Ann, Kumar, Alan Prem, Yong, Wei Peng, Sethi, Gautam, Ho, Paul Chi-Lui, Goh, Boon Cher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161292/
https://www.ncbi.nlm.nih.gov/pubmed/30096831
http://dx.doi.org/10.3390/pharmaceutics10030123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161292/
https://www.ncbi.nlm.nih.gov/pubmed/30096831
http://dx.doi.org/10.3390/pharmaceutics10030123

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