Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

Tau protein forms insoluble filamentous inclusions that are closely associated with nerve cell death in many neurodegenerative diseases. How neurons die in these tauopathies is unclear. We report that living neurons with tau inclusions from P301S-tau mice expose abnormally high amounts of phosphatid...

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Detalles Bibliográficos
Autores principales: Brelstaff, Jack, Tolkovsky, Aviva M., Ghetti, Bernardino, Goedert, Michel, Spillantini, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161320/
https://www.ncbi.nlm.nih.gov/pubmed/30134156
http://dx.doi.org/10.1016/j.celrep.2018.07.072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161320/
https://www.ncbi.nlm.nih.gov/pubmed/30134156
http://dx.doi.org/10.1016/j.celrep.2018.07.072

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