Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-Ig

BACKGROUND: Despite vigorous and ongoing efforts, active immunizations have yet to induce broadly neutralizing antibodies (bNAbs) against HIV-1. An alternative approach is to achieve prophylaxis with long-term expression of potent biologic HIV-1 inhibitors with Adeno-associated Virus (AAV), which co...

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Detalles Bibliográficos
Autores principales: Xu, Ziyang, Wise, Megan C., Choi, Hyeree, Perales-Puchalt, Alfredo, Patel, Ami, Tello-Ruiz, Edgar, Chu, Jacqueline D., Muthumani, Kar, Weiner, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161476/
https://www.ncbi.nlm.nih.gov/pubmed/30174283
http://dx.doi.org/10.1016/j.ebiom.2018.08.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161476/
https://www.ncbi.nlm.nih.gov/pubmed/30174283
http://dx.doi.org/10.1016/j.ebiom.2018.08.027

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