Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible.

To uncover the circuit-level alterations that underlie atypical sensory processing associated with autism, we adopted a symptom-to-circuit approach in the Fmr1(-/-) mouse model of Fragile X syndrome (FXS). Using a go/no-go task and in vivo 2-photon calcium imaging, we find that impaired visual discr...

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Detalles Bibliográficos
Autores principales: Goel, Anubhuti, Cantu, Daniel A., Guilfoyle, Janna, Chaudhari, Gunvant R., Newadkar, Aditi, Todisco, Barbara, de Alba, Diego, Kourdougli, Nazim, Schmitt, Lauren M., Pedapati, Ernest, Erickson, Craig A., Portera-Cailliau, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161491/
https://www.ncbi.nlm.nih.gov/pubmed/30250263
http://dx.doi.org/10.1038/s41593-018-0231-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161491/
https://www.ncbi.nlm.nih.gov/pubmed/30250263
http://dx.doi.org/10.1038/s41593-018-0231-0

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