Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants

Heteromers of Kv7.2/Kv7.3 subunits constitute the main substrate of the neuronal M-current that limits neuronal hyper-excitability and firing frequency. Calmodulin (CaM) binding is essential for surface expression of Kv7 channels, and disruption of this interaction leads to diseases ranging from mil...

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Detalles Bibliográficos
Autores principales: Alaimo, Alessandro, Etxeberria, Ainhoa, Gómez-Posada, Juan Camilo, Gomis-Perez, Carolina, Fernández-Orth, Juncal, Malo, Covadonga, Villarroel, Alvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161613/
https://www.ncbi.nlm.nih.gov/pubmed/30126342
http://dx.doi.org/10.1080/19336950.2018.1511512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161613/
https://www.ncbi.nlm.nih.gov/pubmed/30126342
http://dx.doi.org/10.1080/19336950.2018.1511512

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