Systematic approach demonstrates enrichment of multiple interactions between non-HLA risk variants and HLA-DRB1 risk alleles in rheumatoid arthritis

OBJECTIVE: In anti-citrullinated protein antibody positive rheumatoid arthritis (ACPA-positive RA), a particular subset of HLA-DRB1 alleles, called shared epitope (SE) alleles, is a highly influential genetic risk factor. Here, we investigated whether non-HLA single nucleotide polymorphisms (SNP), c...

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Detalles Bibliográficos
Autores principales: Diaz-Gallo, Lina-Marcela, Ramsköld, Daniel, Shchetynsky, Klementy, Folkersen, Lasse, Chemin, Karine, Brynedal, Boel, Uebe, Steffen, Okada, Yukinori, Alfredsson, Lars, Klareskog, Lars, Padyukov, Leonid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161669/
https://www.ncbi.nlm.nih.gov/pubmed/29967194
http://dx.doi.org/10.1136/annrheumdis-2018-213412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161669/
https://www.ncbi.nlm.nih.gov/pubmed/29967194
http://dx.doi.org/10.1136/annrheumdis-2018-213412

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