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Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review

A major cell defense mechanism against oxidative and xenobiotic stress is mediated by the Nrf2/Keap1 signaling pathway. The Nrf2/Keap1 pathway regulates gene expression of many cytoprotective and detoxifying enzymes, thus playing a pivotal role in maintaining redox cellular homeostasis. Many disease...

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Detalles Bibliográficos
Autores principales:	Sova, Matej, Saso, Luciano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161735/ https://www.ncbi.nlm.nih.gov/pubmed/30288023 http://dx.doi.org/10.2147/DDDT.S172612

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