Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib

Calpains are a family of calcium activated cysteine proteases which participate in a wide range of cellular functions including migration, invasion, autophagy, programmed cell death, and gene expression. Calpain-1 and calpain-2 isoforms are ubiquitously expressed heterodimers composed of isoform spe...

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Detalles Bibliográficos
Autores principales: MacLeod, James A., Gao, Yan, Hall, Christine, Muller, William J., Gujral, Taranjit S., Greer, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161787/
https://www.ncbi.nlm.nih.gov/pubmed/30279968
http://dx.doi.org/10.18632/oncotarget.26078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161787/
https://www.ncbi.nlm.nih.gov/pubmed/30279968
http://dx.doi.org/10.18632/oncotarget.26078

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