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Intratumor heterogeneity of HMCN1 mutant alleles associated with poor prognosis in patients with breast cancer

Human breast cancers comprise a complex and highly heterogeneous population of tumor cells. Intratumor heterogeneity is an underlying cause of resistance to effective therapies and disease recurrence. To explore prognostic factors based on intratumor heterogeneity, we analyzed genomic mutations in b...

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Detalles Bibliográficos
Autores principales: Kikutake, Chie, Yoshihara, Minako, Sato, Tetsuya, Saito, Daisuke, Suyama, Mikita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161790/
https://www.ncbi.nlm.nih.gov/pubmed/30279964
http://dx.doi.org/10.18632/oncotarget.26071