Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial

BACKGROUND: Intravaginal rings (IVRs) for HIV pre-exposure prophylaxis (PrEP) theoretically overcome some adherence concerns associated with frequent dosing that can occur with oral or vaginal film/gel regimens. An innovative pod-IVR, composed of an elastomer scaffold that can hold up to 10 polymer-...

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Detalles Bibliográficos
Autores principales: Vincent, Kathleen L., Moss, John A., Marzinke, Mark A., Hendrix, Craig W., Anton, Peter A., Pyles, Richard B., Guthrie, Kate M., Dawson, Lauren, Olive, Trevelyn J., Butkyavichene, Irina, Churchman, Scott A., Cortez, John M., Fanter, Rob, Gunawardana, Manjula, Miller, Christine S., Yang, Flora, Rosen, Rochelle K., Vargas, Sara E., Baum, Marc M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161852/
https://www.ncbi.nlm.nih.gov/pubmed/30265679
http://dx.doi.org/10.1371/journal.pmed.1002655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161852/
https://www.ncbi.nlm.nih.gov/pubmed/30265679
http://dx.doi.org/10.1371/journal.pmed.1002655

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