Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)

P-glycoprotein (P-gp) is an ABC transporter that exports many amphipathic or hydrophobic compounds, including chemically and functionally dissimilar anticancer drugs, from cells. To understand the role of transmembrane helices (TMH) 1 and 7 in drug-binding and transport, we selected six residues fro...

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Detalles Bibliográficos
Autores principales: Sajid, Andaleeb, Lusvarghi, Sabrina, Chufan, Eduardo E., Ambudkar, Suresh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161881/
https://www.ncbi.nlm.nih.gov/pubmed/30265721
http://dx.doi.org/10.1371/journal.pone.0204693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161881/
https://www.ncbi.nlm.nih.gov/pubmed/30265721
http://dx.doi.org/10.1371/journal.pone.0204693

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