Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus

Autoreactive B cells have a major function in autoimmunity. A small subset of B cells expressing two distinct B-cell-antigen-receptors (B(2R) cells) is elevated in many patients with systematic lupus erythematosus (SLE) and in the MRL(/lpr) mouse model of lupus, and is often autoreactive. Here we sh...

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Detalles Bibliográficos
Autores principales: Sang, Allison, Danhorn, Thomas, Peterson, Jacob N., Rankin, Andrew L., O’Connor, Brian P., Leach, Sonia M., Torres, Raul M., Pelanda, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162205/
https://www.ncbi.nlm.nih.gov/pubmed/30266981
http://dx.doi.org/10.1038/s41467-018-06293-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162205/
https://www.ncbi.nlm.nih.gov/pubmed/30266981
http://dx.doi.org/10.1038/s41467-018-06293-z

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