High-affinity IgM(+) memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen

IgM antibodies (Abs) are thought to play a major role in humoral immunity but only at the early stage of the primary immune response. However, two subsets of IgM(+) memory B cells (MBCs), one with high affinity gained by means of multiple somatic hypermutation (SHM) and the other with low affinity a...

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Detalles Bibliográficos
Autores principales: Tashiro, Yasuyuki, Murakami, Akikazu, Hara, Yasushi, Shimizu, Takeyuki, Kubo, Masato, Goitsuka, Ryo, Kishimoto, Hidehiro, Azuma, Takachika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162211/
https://www.ncbi.nlm.nih.gov/pubmed/30266961
http://dx.doi.org/10.1038/s41598-018-32926-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162211/
https://www.ncbi.nlm.nih.gov/pubmed/30266961
http://dx.doi.org/10.1038/s41598-018-32926-w

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