Cargando…

Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis

Shift metabolism profile from mitochondrial oxidative phosphorylation to aerobic glycolysis (Warburg effect) is a key for tumor cell growth and metastasis. Therefore, suppressing the tumor aerobic glycolysis shows a great promise in anti-tumor therapy. In the present study, we study the role of shik...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Xiaoyue, Zhu, Yanan, Hu, Jianhua, Jiang, Longwei, Li, Limin, Jia, Shaochang, Zen, Ke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162216/ https://www.ncbi.nlm.nih.gov/pubmed/30266938 http://dx.doi.org/10.1038/s41598-018-31615-y

Ejemplares similares

Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms
por: Liu, Jia, et al.
Publicado: (2014)

Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms
por: Rajala, Raju V. S.
Publicado: (2020)

Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis
por: Flora, Gagan D., et al.
Publicado: (2023)

Andrographolide suppresses aerobic glycolysis and induces apoptotic cell death by inhibiting pyruvate dehydrogenase kinase 1 expression
por: Yang, Eun-Sun, et al.
Publicado: (2023)

Shikonin inhibited glycolysis and sensitized cisplatin treatment in non-small cell lung cancer cells via the exosomal pyruvate kinase M2 pathway
por: Dai, Yitian, et al.
Publicado: (2022)

Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation
por: Zhang, Qiqi, et al.
Publicado: (2021)

NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase
por: Gu, Zhimin, et al.
Publicado: (2017)

Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis
por: Guo, Jianshuang, et al.
Publicado: (2019)

Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
por: Shankar Babu, Mani, et al.
Publicado: (2018)

Dihydropyrimidinase Like 2 Promotes Bladder Cancer Progression via Pyruvate Kinase M2-Induced Aerobic Glycolysis and Epithelial–Mesenchymal Transition
por: Zou, Jun, et al.
Publicado: (2021)

Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation
por: Liu, Yun-zi, et al.
Publicado: (2021)

Aerobic glycolysis supports hepatitis B virus protein synthesis through interaction between viral surface antigen and pyruvate kinase isoform M2
por: Wu, Yi-Hsuan, et al.
Publicado: (2021)

Reprogramming of aerobic glycolysis in non‐transformed mouse liver with pyruvate dehydrogenase complex deficiency
por: Patel, Mulchand S., et al.
Publicado: (2021)

Myeloid-Specific Pyruvate-Kinase-Type-M2-Deficient Mice Are Resistant to Acute Lung Injury
por: Sun, Xinlei, et al.
Publicado: (2022)

Pyruvate Kinase M2 Coordinates Metabolism Switch between Glycolysis and Glutaminolysis in Cancer Cells
por: Li, Liangwei, et al.
Publicado: (2020)

Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2
por: van de Wetering, Cheryl, et al.
Publicado: (2021)

Corrigendum: Reprogramming of aerobic glycolysis in non‐transformed mouse liver with pyruvate dehydrogenase complex deficiency
Publicado: (2021)

Small ubiquitin-like modifier 1 modification of pyruvate kinase M2 promotes aerobic glycolysis and cell proliferation in A549 human lung cancer cells
por: An, Shuxian, et al.
Publicado: (2018)

Pantothenate Kinase 4 Governs Lens Epithelial Fibrosis by Negatively Regulating Pyruvate Kinase M2-Related Glycolysis
por: Li, Xue, et al.
Publicado: (2023)

MUC1-C Oncoprotein Regulates Glycolysis and Pyruvate Kinase m2 Activity in Cancer Cells
por: Kosugi, Michio, et al.
Publicado: (2011)

HSP40 Interacts with Pyruvate Kinase M2 and Regulates Glycolysis and Cell Proliferation in Tumor Cells
por: Huang, Liangqian, et al.
Publicado: (2014)

MiR‐5683 suppresses glycolysis and proliferation through targeting pyruvate dehydrogenase kinase 4 in gastric cancer
por: Miao, Yongchang, et al.
Publicado: (2020)

Shikonin Inhibits the Proliferation of Human Breast Cancer Cells by Reducing Tumor-Derived Exosomes
por: Wei, Yao, et al.
Publicado: (2016)

Shikonin reverses pyruvate kinase isoform M2‐mediated propranolol resistance in infantile hemangioma through reactive oxygen species‐induced autophagic dysfunction
por: Yang, Enli, et al.
Publicado: (2022)

Pyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis
por: Ricci, Luisa, et al.
Publicado: (2023)

Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation
por: Coassolo, Sébastien, et al.
Publicado: (2021)

Pyruvate Kinase M2 Accelerates Cutaneous Wound Healing via Glycolysis and Wnt/β-Catenin Signaling
por: Kim, Eunhwan, et al.
Publicado: (2023)

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
por: Davidson, Shawn M., et al.
Publicado: (2022)

Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation
por: Yuan, Qi, et al.
Publicado: (2020)

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
por: Anastasiou, Dimitrios, et al.
Publicado: (2012)

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis
por: Zhan, Cheng, et al.
Publicado: (2015)

iNOS-derived nitric oxide promotes glycolysis by inducing pyruvate kinase M2 nuclear translocation in ovarian cancer
por: Li, Linlin, et al.
Publicado: (2017)

Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
por: Almouhanna, Fadi, et al.
Publicado: (2021)

Blocking Aerobic Glycolysis by Targeting Pyruvate Dehydrogenase Kinase in Combination with EGFR TKI and Ionizing Radiation Increases Therapeutic Effect in Non-Small Cell Lung Cancer Cells
por: Dyrstad, Sissel E., et al.
Publicado: (2021)

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
por: Wei, Yao, et al.
Publicado: (2017)

Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication
por: Horemans, Steff, et al.
Publicado: (2022)

Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death
por: Li, Sainan, et al.
Publicado: (2017)

Aerobic Glycolysis: Beyond Proliferation
por: Jones, William, et al.
Publicado: (2015)

LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2
por: Jia, Guizhi, et al.
Publicado: (2021)

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
por: Wang, Xiuxiu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9hotl9eejuihjqhgs8ln18ki4n