Doxorubicin induces caspase-mediated proteolysis of KV7.1

K(v)7.1 (KCNQ1) coassembles with KCNE1 to generate the cardiac I(Ks)-channel. Gain- and loss-of-function mutations in KCNQ1 are associated with cardiac arrhthymias, highlighting the importance of modulating I(Ks) activity for cardiac function. Here, we report proteolysis of K(v)7.1 as an irreversibl...

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Detalles Bibliográficos
Autores principales: Strigli, Anne, Raab, Christian, Hessler, Sabine, Huth, Tobias, Schuldt, Adam J. T., Alzheimer, Christian, Friedrich, Thomas, Burridge, Paul W., Luedde, Mark, Schwake, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162258/
https://www.ncbi.nlm.nih.gov/pubmed/30302399
http://dx.doi.org/10.1038/s42003-018-0162-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162258/
https://www.ncbi.nlm.nih.gov/pubmed/30302399
http://dx.doi.org/10.1038/s42003-018-0162-z

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