A minimal helical-hairpin motif provides molecular-level insights into misfolding and pharmacological rescue of CFTR

Our meagre understanding of CFTR misfolding and its reversal by small-molecule correctors hampers the development of mechanism-based therapies of cystic fibrosis. Here we exploit a helical-hairpin construct—the simplest proxy of membrane-protein tertiary contacts—containing CFTR’s transmembrane heli...

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Detalles Bibliográficos
Autores principales: Krainer, Georg, Treff, Antoine, Hartmann, Andreas, Stone, Tracy A., Schenkel, Mathias, Keller, Sandro, Deber, Charles M., Schlierf, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162264/
https://www.ncbi.nlm.nih.gov/pubmed/30302398
http://dx.doi.org/10.1038/s42003-018-0153-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162264/
https://www.ncbi.nlm.nih.gov/pubmed/30302398
http://dx.doi.org/10.1038/s42003-018-0153-0

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