GLS-409, an Antagonist of Both P2Y(1) and P2Y(12), Potently Inhibits Canine Coronary Artery Thrombosis and Reversibly Inhibits Human Platelet Activation

Dual antiplatelet therapy with aspirin and an adenosine diphosphate (ADP) P2Y(12) receptor antagonist reduces ischemic events in patients with acute coronary syndrome. Previous evidence from our group, obtained in a preclinical model of recurrent platelet-mediated thrombosis, demonstrated that GLS-4...

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Detalles Bibliográficos
Autores principales: Smolensky Koganov, Elena, Michelson, Alan D., Yanachkov, Ivan B., Yanachkova, Milka I., Wright, George E., Przyklenk, Karin, Frelinger, Andrew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162268/
https://www.ncbi.nlm.nih.gov/pubmed/30266987
http://dx.doi.org/10.1038/s41598-018-32797-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162268/
https://www.ncbi.nlm.nih.gov/pubmed/30266987
http://dx.doi.org/10.1038/s41598-018-32797-1

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