Cargando…

The lipid mediator lysophosphatidic acid induces folding of disordered peptides with basic amphipathic character into rare conformations

Membrane-active, basic amphipathic peptides represent a class of biomolecules with diverse functions. Sequentially close protein segments also show similar behaviour in several ways. Here we investigated the effect of the lipid mediator lysophosphatidic acid (LPA) on the conformation of structurally...

Descripción completa

Detalles Bibliográficos
Autores principales:	Juhász, Tünde, Mihály, Judith, Kohut, Gergely, Németh, Csaba, Liliom, Károly, Beke-Somfai, Tamás
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162328/ https://www.ncbi.nlm.nih.gov/pubmed/30266943 http://dx.doi.org/10.1038/s41598-018-32786-4

Ejemplares similares

Controlling Peptide Function by Directed Assembly Formation: Mechanistic Insights Using Multiscale Modeling on an Antimicrobial Peptide–Drug–Membrane System
por: Kohut, Gergely, et al.
Publicado: (2021)

Comparison of ligand binding and conformational stability of human calmodulin with its homolog from the malaria parasite Plasmodium falciparum
por: Juhász, Tünde, et al.
Publicado: (2020)

Membrane active Janus-oligomers of β(3)-peptides
por: Szigyártó, Imola Cs., et al.
Publicado: (2020)

Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity
por: Quemé‐Peña, Mayra, et al.
Publicado: (2019)

Membrane Association Modes of Natural Anticancer Peptides: Mechanistic Details on Helicity, Orientation, and Surface Coverage
por: Quemé-Peña, Mayra, et al.
Publicado: (2021)

Interplay between membrane active host defense peptides and heme modulates their assemblies and in vitro activity
por: Juhász, Tünde, et al.
Publicado: (2021)

Structures of calmodulin–melittin complexes show multiple binding modes lacking classical anchoring interactions
por: Dürvanger, Zsolt, et al.
Publicado: (2023)

Comparative Study of Molecular Mechanics Force Fields for β-Peptidic Foldamers: Folding and Self-Association
por: Wacha, András, et al.
Publicado: (2023)

Storage conditions determine the characteristics of red blood cell derived extracellular vesicles
por: Bebesi, Tímea, et al.
Publicado: (2022)

Membrane Active Peptides Remove Surface Adsorbed Protein Corona From Extracellular Vesicles of Red Blood Cells
por: Singh, Priyanka, et al.
Publicado: (2020)

Detection and phenotyping of extracellular vesicles by size exclusion chromatography coupled with on-line fluorescence detection
por: Kitka, Diána, et al.
Publicado: (2019)

Conformational properties of 1,4- and 1,5-substituted 1,2,3-triazole amino acids – building units for peptidic foldamers
por: Kann, Nina, et al.
Publicado: (2015)

Stimuli-Responsive Membrane Anchor Peptide Nanofoils for Tunable Membrane Association and Lipid Bilayer Fusion
por: Udyavara Nagaraj, Vignesh, et al.
Publicado: (2022)

Solution NMR Structure of the SH3 Domain of Human Caskin1 Validates the Lack of a Typical Peptide Binding Groove and Supports a Role in Lipid Mediator Binding
por: Tőke, Orsolya, et al.
Publicado: (2021)

Structural Water Stabilizes Protein Motifs in Liquid Protein Phase: The Folding Mechanism of Short β-Sheets Coupled to Phase Transition
por: Papp, Dóra, et al.
Publicado: (2021)

Improved Modeling of Peptidic Foldamers Using a Quantum Chemical Parametrization Based on Torsional Minimum Energy Path Matching
por: Wacha, András, et al.
Publicado: (2019)

Neuronal-specific septin-3 binds Atg8/LC3B, accumulates and localizes to autophagosomes during induced autophagy
por: Tóth, Vilmos, et al.
Publicado: (2022)

Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes
por: Ádám, Csaba, et al.
Publicado: (2015)

Facially Amphipathic Glycopolymers Inhibit Ice Recrystallization
por: Graham, Ben, et al.
Publicado: (2018)

The Many Faces of Amphipathic Helices
por: Giménez-Andrés, Manuel, et al.
Publicado: (2018)

Reagent-free total protein quantification of intact extracellular vesicles by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy
por: Szentirmai, Veronika, et al.
Publicado: (2020)

Glycogen phosphorylase inhibitor, 2,3‐bis[(2E)‐3‐(4‐hydroxyphenyl)prop‐2‐enamido] butanedioic acid (BF142), improves baseline insulin secretion of MIN6 insulinoma cells
por: Nagy, Lilla, et al.
Publicado: (2020)

Single-particle detection of native SARS-CoV-2 virions by microfluidic resistive pulse sensing
por: Varga, Zoltán, et al.
Publicado: (2022)

Preparation and Characterization of an Amphipathic Magnetic Nanosphere
por: Ji, Yongsheng, et al.
Publicado: (2014)

Interaction of Terminal Oxidases with Amphipathic Molecules
por: Azarkina, Natalia V., et al.
Publicado: (2023)

Characterization of the Thermal and Photoinduced Reactions of Photochromic Spiropyrans in Aqueous Solution
por: Hammarson, Martin, et al.
Publicado: (2013)

ConjuPepDB: a database of peptide–drug conjugates
por: Balogh, Balázs, et al.
Publicado: (2020)

Quorum Sensing Pseudomonas Quinolone Signal Forms Chiral Supramolecular Assemblies With the Host Defense Peptide LL-37
por: Zsila, Ferenc, et al.
Publicado: (2021)

Conformations and forces in protein folding
Publicado: (1991)

Vorescore—fold recognition improved by rescoring of protein structure models
por: Csaba, Gergely, et al.
Publicado: (2010)

Prediction of amphipathic helix—membrane interactions with Rosetta
por: Gulsevin, Alican, et al.
Publicado: (2021)

Asymmetric effects of amphipathic molecules on mechanosensitive channels
por: Bavi, Omid, et al.
Publicado: (2022)

In Silico Structural Analysis Exploring Conformational Folding of Protein Variants in Alzheimer’s Disease
por: Efraimidis, Evangelos, et al.
Publicado: (2023)

Absolute Quantitation of Serum Antibody Reactivity Using the Richards Growth Model for Antigen Microspot Titration
por: Papp, Krisztián, et al.
Publicado: (2022)

Highly potent dUTPase inhibition by a bacterial repressor protein reveals a novel mechanism for gene expression control
por: Szabó, Judit E., et al.
Publicado: (2014)

Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models
por: Mátyás, Csaba, et al.
Publicado: (2018)

Small amphipathic peptides are responsible for the assembly of cruciferin nanoparticles
por: Hong, Hui, et al.
Publicado: (2017)

Coemergence of the Amphipathic Helix on Ameloblastin With Mammalian Prismatic Enamel
por: Su, Jingtan, et al.
Publicado: (2022)

2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition
por: Fukasawa, Keiko, et al.
Publicado: (2021)

Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis
por: Yang, Bicheng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_f6a9a99uon6as2ea6blavridji