Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging

Adaptive immunity involves the development of bespoke antibodies in germinal centers (GCs) through immunoglobulin somatic hypermutation (SHM) in GC dark zones (DZs) and clonal selection in light zones (LZs). Accurate selection requires that cells fully replace surface B cell receptors (BCRs) followi...

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Detalles Bibliográficos
Autores principales: Stewart, Isabelle, Radtke, Daniel, Phillips, Bethan, McGowan, Simon J., Bannard, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162340/
https://www.ncbi.nlm.nih.gov/pubmed/30231983
http://dx.doi.org/10.1016/j.immuni.2018.08.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162340/
https://www.ncbi.nlm.nih.gov/pubmed/30231983
http://dx.doi.org/10.1016/j.immuni.2018.08.025

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