The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway

Due to their role in many diseases, enzymes of the ubiquitin system have recently become interesting drug targets. Despite efforts, primary screenings of compound libraries targeting E2 enzymes and E3 ligases have been strongly limited by the lack of robust and fast high-throughput assays. Here we r...

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Detalles Bibliográficos
Autores principales: De Cesare, Virginia, Johnson, Clare, Barlow, Victoria, Hastie, James, Knebel, Axel, Trost, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162346/
https://www.ncbi.nlm.nih.gov/pubmed/30017913
http://dx.doi.org/10.1016/j.chembiol.2018.06.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162346/
https://www.ncbi.nlm.nih.gov/pubmed/30017913
http://dx.doi.org/10.1016/j.chembiol.2018.06.004

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