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Targeting Raf Kinase Inhibitory Protein Regulation and Function

Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals mol...

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Detalles Bibliográficos
Autores principales: Yesilkanal, Ali Ekrem, Rosner, Marsha Rich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162369/
https://www.ncbi.nlm.nih.gov/pubmed/30181452
http://dx.doi.org/10.3390/cancers10090306
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author Yesilkanal, Ali Ekrem
Rosner, Marsha Rich
author_facet Yesilkanal, Ali Ekrem
Rosner, Marsha Rich
author_sort Yesilkanal, Ali Ekrem
collection PubMed
description Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals molecular mechanisms that regulate metastasis, but also represents an opportunity to target these signaling networks therapeutically. Although RKIP is often lost during metastatic progression, the mechanism by which this occurs in tumor cells is complex and not well understood. In this review, we summarize our current understanding of RKIP regulation in tumors and consider experimental and computational strategies for recovering or mimicking its function by targeting mediators of metastasis.
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spelling pubmed-61623692018-10-02 Targeting Raf Kinase Inhibitory Protein Regulation and Function Yesilkanal, Ali Ekrem Rosner, Marsha Rich Cancers (Basel) Review Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals molecular mechanisms that regulate metastasis, but also represents an opportunity to target these signaling networks therapeutically. Although RKIP is often lost during metastatic progression, the mechanism by which this occurs in tumor cells is complex and not well understood. In this review, we summarize our current understanding of RKIP regulation in tumors and consider experimental and computational strategies for recovering or mimicking its function by targeting mediators of metastasis. MDPI 2018-09-04 /pmc/articles/PMC6162369/ /pubmed/30181452 http://dx.doi.org/10.3390/cancers10090306 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yesilkanal, Ali Ekrem
Rosner, Marsha Rich
Targeting Raf Kinase Inhibitory Protein Regulation and Function
title Targeting Raf Kinase Inhibitory Protein Regulation and Function
title_full Targeting Raf Kinase Inhibitory Protein Regulation and Function
title_fullStr Targeting Raf Kinase Inhibitory Protein Regulation and Function
title_full_unstemmed Targeting Raf Kinase Inhibitory Protein Regulation and Function
title_short Targeting Raf Kinase Inhibitory Protein Regulation and Function
title_sort targeting raf kinase inhibitory protein regulation and function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162369/
https://www.ncbi.nlm.nih.gov/pubmed/30181452
http://dx.doi.org/10.3390/cancers10090306
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