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Targeting Raf Kinase Inhibitory Protein Regulation and Function
Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals mol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162369/ https://www.ncbi.nlm.nih.gov/pubmed/30181452 http://dx.doi.org/10.3390/cancers10090306 |
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author | Yesilkanal, Ali Ekrem Rosner, Marsha Rich |
author_facet | Yesilkanal, Ali Ekrem Rosner, Marsha Rich |
author_sort | Yesilkanal, Ali Ekrem |
collection | PubMed |
description | Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals molecular mechanisms that regulate metastasis, but also represents an opportunity to target these signaling networks therapeutically. Although RKIP is often lost during metastatic progression, the mechanism by which this occurs in tumor cells is complex and not well understood. In this review, we summarize our current understanding of RKIP regulation in tumors and consider experimental and computational strategies for recovering or mimicking its function by targeting mediators of metastasis. |
format | Online Article Text |
id | pubmed-6162369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61623692018-10-02 Targeting Raf Kinase Inhibitory Protein Regulation and Function Yesilkanal, Ali Ekrem Rosner, Marsha Rich Cancers (Basel) Review Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals molecular mechanisms that regulate metastasis, but also represents an opportunity to target these signaling networks therapeutically. Although RKIP is often lost during metastatic progression, the mechanism by which this occurs in tumor cells is complex and not well understood. In this review, we summarize our current understanding of RKIP regulation in tumors and consider experimental and computational strategies for recovering or mimicking its function by targeting mediators of metastasis. MDPI 2018-09-04 /pmc/articles/PMC6162369/ /pubmed/30181452 http://dx.doi.org/10.3390/cancers10090306 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yesilkanal, Ali Ekrem Rosner, Marsha Rich Targeting Raf Kinase Inhibitory Protein Regulation and Function |
title | Targeting Raf Kinase Inhibitory Protein Regulation and Function |
title_full | Targeting Raf Kinase Inhibitory Protein Regulation and Function |
title_fullStr | Targeting Raf Kinase Inhibitory Protein Regulation and Function |
title_full_unstemmed | Targeting Raf Kinase Inhibitory Protein Regulation and Function |
title_short | Targeting Raf Kinase Inhibitory Protein Regulation and Function |
title_sort | targeting raf kinase inhibitory protein regulation and function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162369/ https://www.ncbi.nlm.nih.gov/pubmed/30181452 http://dx.doi.org/10.3390/cancers10090306 |
work_keys_str_mv | AT yesilkanalaliekrem targetingrafkinaseinhibitoryproteinregulationandfunction AT rosnermarsharich targetingrafkinaseinhibitoryproteinregulationandfunction |