Phosphorylation-Dependent Inhibition of Akt1

Protein kinase B (Akt1) is a proto-oncogene that is overactive in most cancers. Akt1 activation requires phosphorylation at Thr308; phosphorylation at Ser473 further enhances catalytic activity. Akt1 activity is also regulated via interactions between the kinase domain and the N-terminal auto-inhibi...

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Detalles Bibliográficos
Autores principales: Balasuriya, Nileeka, McKenna, McShane, Liu, Xuguang, Li, Shawn S. C., O’Donoghue, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162393/
https://www.ncbi.nlm.nih.gov/pubmed/30205513
http://dx.doi.org/10.3390/genes9090450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162393/
https://www.ncbi.nlm.nih.gov/pubmed/30205513
http://dx.doi.org/10.3390/genes9090450

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