A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers

Background: Insulin-like growth factor I (IGF-I) and other markers of insulin resistance (IRm) might influence the penetrance of BRCA gene mutation. In a demonstration project on BRCA mutation carriers we tested the effect of the ‘Mediterranean diet’, with moderate protein restriction, on serum leve...

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Autores principales: Pasanisi, Patrizia, Bruno, Eleonora, Venturelli, Elisabetta, Morelli, Daniele, Oliverio, Andreina, Baldassari, Ivan, Rovera, Francesca, Iula, Giovanna, Taborelli, Monica, Peissel, Bernard, Azzollini, Jacopo, Manoukian, Siranoush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162406/
https://www.ncbi.nlm.nih.gov/pubmed/30181513
http://dx.doi.org/10.3390/cancers10090309
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author Pasanisi, Patrizia
Bruno, Eleonora
Venturelli, Elisabetta
Morelli, Daniele
Oliverio, Andreina
Baldassari, Ivan
Rovera, Francesca
Iula, Giovanna
Taborelli, Monica
Peissel, Bernard
Azzollini, Jacopo
Manoukian, Siranoush
author_facet Pasanisi, Patrizia
Bruno, Eleonora
Venturelli, Elisabetta
Morelli, Daniele
Oliverio, Andreina
Baldassari, Ivan
Rovera, Francesca
Iula, Giovanna
Taborelli, Monica
Peissel, Bernard
Azzollini, Jacopo
Manoukian, Siranoush
author_sort Pasanisi, Patrizia
collection PubMed
description Background: Insulin-like growth factor I (IGF-I) and other markers of insulin resistance (IRm) might influence the penetrance of BRCA gene mutation. In a demonstration project on BRCA mutation carriers we tested the effect of the ‘Mediterranean diet’, with moderate protein restriction, on serum levels of IGF-I and IRm. Methods: BRCA mutation carriers, with or without breast cancer, aged 18–70 years and without metastases were eligible. After the baseline examinations, women were randomized to an active dietary intervention or to a control group. The intervention group attended six full days of life-style intervention activities (cookery classes followed by lunch, sessions of walking for 45 min and nutritional conferences) over the next six months. Results: 213 BRCA mutation carriers completed the six-month study. Women in the intervention group (110) showed major changes in all the parameters under study. They significantly lost weight (p < 0.001), fat mass (p = 0.002), with reduced hip circumference (p = 0.01), triglycerides (p = 0.02) and IGF-I (p = 0.02) compared with controls. They also had a significantly higher levels of insulin-like growth factor-binding protein 3 (IGFI-BP3) (p = 0.03) and a lower IGF-I/IGFI-BP3 ratio (p = 0.04). The reduction of serum levels of IGF-I was significantly associated with the reduction in the consumption of animal products (p = 0.04). Conclusions: Women in the intervention group showed significant improvements in IGF-I and in other IRm that might influence the penetrance of BRCA mutations.
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spelling pubmed-61624062018-10-02 A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers Pasanisi, Patrizia Bruno, Eleonora Venturelli, Elisabetta Morelli, Daniele Oliverio, Andreina Baldassari, Ivan Rovera, Francesca Iula, Giovanna Taborelli, Monica Peissel, Bernard Azzollini, Jacopo Manoukian, Siranoush Cancers (Basel) Article Background: Insulin-like growth factor I (IGF-I) and other markers of insulin resistance (IRm) might influence the penetrance of BRCA gene mutation. In a demonstration project on BRCA mutation carriers we tested the effect of the ‘Mediterranean diet’, with moderate protein restriction, on serum levels of IGF-I and IRm. Methods: BRCA mutation carriers, with or without breast cancer, aged 18–70 years and without metastases were eligible. After the baseline examinations, women were randomized to an active dietary intervention or to a control group. The intervention group attended six full days of life-style intervention activities (cookery classes followed by lunch, sessions of walking for 45 min and nutritional conferences) over the next six months. Results: 213 BRCA mutation carriers completed the six-month study. Women in the intervention group (110) showed major changes in all the parameters under study. They significantly lost weight (p < 0.001), fat mass (p = 0.002), with reduced hip circumference (p = 0.01), triglycerides (p = 0.02) and IGF-I (p = 0.02) compared with controls. They also had a significantly higher levels of insulin-like growth factor-binding protein 3 (IGFI-BP3) (p = 0.03) and a lower IGF-I/IGFI-BP3 ratio (p = 0.04). The reduction of serum levels of IGF-I was significantly associated with the reduction in the consumption of animal products (p = 0.04). Conclusions: Women in the intervention group showed significant improvements in IGF-I and in other IRm that might influence the penetrance of BRCA mutations. MDPI 2018-09-04 /pmc/articles/PMC6162406/ /pubmed/30181513 http://dx.doi.org/10.3390/cancers10090309 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pasanisi, Patrizia
Bruno, Eleonora
Venturelli, Elisabetta
Morelli, Daniele
Oliverio, Andreina
Baldassari, Ivan
Rovera, Francesca
Iula, Giovanna
Taborelli, Monica
Peissel, Bernard
Azzollini, Jacopo
Manoukian, Siranoush
A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers
title A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers
title_full A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers
title_fullStr A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers
title_full_unstemmed A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers
title_short A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers
title_sort dietary intervention to lower serum levels of igf-i in brca mutation carriers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162406/
https://www.ncbi.nlm.nih.gov/pubmed/30181513
http://dx.doi.org/10.3390/cancers10090309
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