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Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair
DNA repair systems are abnormally active in most hepatocellular carcinoma (HCC) cells due to accumulated mutations, resulting in elevated DNA repair capacity and resistance to chemotherapy and radiotherapy. Thus, targeting DNA repair mechanisms is a common treatment approach in HCC to sensitize canc...
Autores principales: | Chen, Chin-Chuan, Chen, Chi-Yuan, Wang, Shu-Huei, Yeh, Chau-Ting, Su, Shih-Chi, Ueng, Shir-Hwa, Chuang, Wen-Yu, Hsueh, Chuen, Wang, Tong-Hong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162454/ https://www.ncbi.nlm.nih.gov/pubmed/30201872 http://dx.doi.org/10.3390/cancers10090320 |
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