Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy

A better understanding of mechanistic insights into genes and enzymes implicated in rare diseases provide a unique opportunity for orphan drug development. Advances made in identification of synthetic lethal relationships between rare disorder genes with oncogenes and tumor suppressor genes have bro...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhattacharjee, Sonali, Nandi, Saikat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162646/
https://www.ncbi.nlm.nih.gov/pubmed/30200453
http://dx.doi.org/10.3390/cancers10090298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162646/
https://www.ncbi.nlm.nih.gov/pubmed/30200453
http://dx.doi.org/10.3390/cancers10090298

Ejemplares similares