Interaction of 2′R-ochratoxin A with Serum Albumins: Binding Site, Effects of Site Markers, Thermodynamics, Species Differences of Albumin-binding, and Influence of Albumin on Its Toxicity in MDCK Cells

Ochratoxin A (OTA) is a nephrotoxic mycotoxin. Roasting of OTA-contaminated coffee results in the formation of 2′R-ochratoxin A (2′R-OTA), which appears in the blood of coffee drinkers. Human serum albumin (HSA) binds 2′R-OTA (and OTA) with high affinity; therefore, albumin may influence the tissue...

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Detalles Bibliográficos
Autores principales: Faisal, Zelma, Derdák, Diána, Lemli, Beáta, Kunsági-Máté, Sándor, Bálint, Mónika, Hetényi, Csaba, Csepregi, Rita, Kőszegi, Tamás, Sueck, Franziska, Cramer, Benedikt, Humpf, Hans-Ulrich, Poór, Miklós
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162703/
https://www.ncbi.nlm.nih.gov/pubmed/30200461
http://dx.doi.org/10.3390/toxins10090353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162703/
https://www.ncbi.nlm.nih.gov/pubmed/30200461
http://dx.doi.org/10.3390/toxins10090353

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