Clonal Heterogeneity Reflected by PI3K-AKT-mTOR Signaling in Human Acute Myeloid Leukemia Cells and Its Association with Adverse Prognosis

Clonal heterogeneity detected by karyotyping is a biomarker associated with adverse prognosis in acute myeloid leukemia (AML). Constitutive activation of the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin (PI3K-Akt-mTOR) pathway is present in AML cells, and this pathway integrates...

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Detalles Bibliográficos
Autores principales: Nepstad, Ina, Hatfield, Kimberley Joanne, Tvedt, Tor Henrik Anderson, Reikvam, Håkon, Bruserud, Øystein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162751/
https://www.ncbi.nlm.nih.gov/pubmed/30223538
http://dx.doi.org/10.3390/cancers10090332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162751/
https://www.ncbi.nlm.nih.gov/pubmed/30223538
http://dx.doi.org/10.3390/cancers10090332

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