Peptide Mimics of the Ribosomal P Stalk Inhibit the Activity of Ricin A Chain by Preventing Ribosome Binding

Ricin A chain (RTA) depurinates the sarcin/ricin loop (SRL) by interacting with the C-termini of the ribosomal P stalk. The ribosome interaction site and the active site are located on opposite faces of RTA. The interaction with P proteins allows RTA to depurinate the SRL on the ribosome at physiolo...

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Detalles Bibliográficos
Autores principales: Li, Xiao-Ping, Kahn, Jennifer N., Tumer, Nilgun E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162817/
https://www.ncbi.nlm.nih.gov/pubmed/30217009
http://dx.doi.org/10.3390/toxins10090371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162817/
https://www.ncbi.nlm.nih.gov/pubmed/30217009
http://dx.doi.org/10.3390/toxins10090371

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