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Selection for Protein Stability Enriches for Epistatic Interactions

A now classical argument for the marginal thermodynamic stability of proteins explains the distribution of observed protein stabilities as a consequence of an entropic pull in protein sequence space. In particular, most sequences that are sufficiently stable to fold will have stabilities near the fo...

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Detalles Bibliográficos
Autores principales: Posfai, Anna, Zhou, Juannan, Plotkin, Joshua B., Kinney, Justin B., McCandlish, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162820/
https://www.ncbi.nlm.nih.gov/pubmed/30134605
http://dx.doi.org/10.3390/genes9090423