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The prostaglandin D(2) receptor 2 pathway in asthma: a key player in airway inflammation

Asthma is characterised by chronic airway inflammation, airway obstruction and hyper-responsiveness. The inflammatory cascade in asthma comprises a complex interplay of genetic factors, the airway epithelium, and dysregulation of the immune response. Prostaglandin D(2) (PGD(2)) is a lipid mediator,...

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Autores principales: Domingo, Christian, Palomares, Oscar, Sandham, David A., Erpenbeck, Veit J., Altman, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162887/
https://www.ncbi.nlm.nih.gov/pubmed/30268119
http://dx.doi.org/10.1186/s12931-018-0893-x
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author Domingo, Christian
Palomares, Oscar
Sandham, David A.
Erpenbeck, Veit J.
Altman, Pablo
author_facet Domingo, Christian
Palomares, Oscar
Sandham, David A.
Erpenbeck, Veit J.
Altman, Pablo
author_sort Domingo, Christian
collection PubMed
description Asthma is characterised by chronic airway inflammation, airway obstruction and hyper-responsiveness. The inflammatory cascade in asthma comprises a complex interplay of genetic factors, the airway epithelium, and dysregulation of the immune response. Prostaglandin D(2) (PGD(2)) is a lipid mediator, predominantly released from mast cells, but also by other immune cells such as T(H)2 cells and dendritic cells, which plays a significant role in the pathophysiology of asthma. PGD(2) mainly exerts its biological functions via two G-protein-coupled receptors, the PGD(2) receptor 1 (DP(1)) and 2 (DP(2)). The DP(2) receptor is mainly expressed by the key cells involved in type 2 immune responses, including T(H)2 cells, type 2 innate lymphoid cells and eosinophils. The DP(2) receptor pathway is a novel and important therapeutic target for asthma, because increased PGD(2) production induces significant inflammatory cell chemotaxis and degranulation via its interaction with the DP(2) receptor. This interaction has serious consequences in the pulmonary milieu, including the release of pro-inflammatory cytokines and harmful cationic proteases, leading to tissue remodelling, mucus production, structural damage, and compromised lung function. This review will discuss the importance of the DP(2) receptor pathway and the current understanding of its role in asthma.
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spelling pubmed-61628872018-10-01 The prostaglandin D(2) receptor 2 pathway in asthma: a key player in airway inflammation Domingo, Christian Palomares, Oscar Sandham, David A. Erpenbeck, Veit J. Altman, Pablo Respir Res Review Asthma is characterised by chronic airway inflammation, airway obstruction and hyper-responsiveness. The inflammatory cascade in asthma comprises a complex interplay of genetic factors, the airway epithelium, and dysregulation of the immune response. Prostaglandin D(2) (PGD(2)) is a lipid mediator, predominantly released from mast cells, but also by other immune cells such as T(H)2 cells and dendritic cells, which plays a significant role in the pathophysiology of asthma. PGD(2) mainly exerts its biological functions via two G-protein-coupled receptors, the PGD(2) receptor 1 (DP(1)) and 2 (DP(2)). The DP(2) receptor is mainly expressed by the key cells involved in type 2 immune responses, including T(H)2 cells, type 2 innate lymphoid cells and eosinophils. The DP(2) receptor pathway is a novel and important therapeutic target for asthma, because increased PGD(2) production induces significant inflammatory cell chemotaxis and degranulation via its interaction with the DP(2) receptor. This interaction has serious consequences in the pulmonary milieu, including the release of pro-inflammatory cytokines and harmful cationic proteases, leading to tissue remodelling, mucus production, structural damage, and compromised lung function. This review will discuss the importance of the DP(2) receptor pathway and the current understanding of its role in asthma. BioMed Central 2018-09-29 2018 /pmc/articles/PMC6162887/ /pubmed/30268119 http://dx.doi.org/10.1186/s12931-018-0893-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Domingo, Christian
Palomares, Oscar
Sandham, David A.
Erpenbeck, Veit J.
Altman, Pablo
The prostaglandin D(2) receptor 2 pathway in asthma: a key player in airway inflammation
title The prostaglandin D(2) receptor 2 pathway in asthma: a key player in airway inflammation
title_full The prostaglandin D(2) receptor 2 pathway in asthma: a key player in airway inflammation
title_fullStr The prostaglandin D(2) receptor 2 pathway in asthma: a key player in airway inflammation
title_full_unstemmed The prostaglandin D(2) receptor 2 pathway in asthma: a key player in airway inflammation
title_short The prostaglandin D(2) receptor 2 pathway in asthma: a key player in airway inflammation
title_sort prostaglandin d(2) receptor 2 pathway in asthma: a key player in airway inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162887/
https://www.ncbi.nlm.nih.gov/pubmed/30268119
http://dx.doi.org/10.1186/s12931-018-0893-x
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