From association to mechanism in complex disease genetics: the role of the 3D genome

Genome-wide association studies (GWAS) and fine mapping studies in autoimmune diseases have identified thousands of genetic variants, the majority of which are located in non-protein-coding enhancer regions. Enhancers function within the context of the three-dimensional (3D) genome to form long-rang...

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Detalles Bibliográficos
Autores principales: Fu, Yao, Tessneer, Kandice L, Li, Chuang, Gaffney, Patrick M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162955/
https://www.ncbi.nlm.nih.gov/pubmed/30268153
http://dx.doi.org/10.1186/s13075-018-1721-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162955/
https://www.ncbi.nlm.nih.gov/pubmed/30268153
http://dx.doi.org/10.1186/s13075-018-1721-x

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