Population dynamics of normal human blood inferred from somatic mutations

Haematopoietic stem cells drive blood production, but their population size and lifetime dynamics have not been directly quantified in humans. We identified 129,582 spontaneous, genome-wide somatic mutations in 140 single-cell–derived haematopoietic stem and progenitor colonies from a normal 59 year...

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Detalles Bibliográficos
Autores principales: Lee-Six, Henry, Øbro, Nina Friesgaard, Shepherd, Mairi S., Grossmann, Sebastian, Dawson, Kevin, Belmonte, Miriam, Osborne, Robert J., Huntly, Brian J. P., Martincorena, Inigo, Anderson, Elizabeth, O’Neill, Laura, Stratton, Michael R., Laurenti, Elisa, Green, Anthony R., Kent, David G., Campbell, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163040/
https://www.ncbi.nlm.nih.gov/pubmed/30185910
http://dx.doi.org/10.1038/s41586-018-0497-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163040/
https://www.ncbi.nlm.nih.gov/pubmed/30185910
http://dx.doi.org/10.1038/s41586-018-0497-0

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