Cargando…

Population dynamics of normal human blood inferred from somatic mutations

Haematopoietic stem cells drive blood production, but their population size and lifetime dynamics have not been directly quantified in humans. We identified 129,582 spontaneous, genome-wide somatic mutations in 140 single-cell–derived haematopoietic stem and progenitor colonies from a normal 59 year...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee-Six, Henry, Øbro, Nina Friesgaard, Shepherd, Mairi S., Grossmann, Sebastian, Dawson, Kevin, Belmonte, Miriam, Osborne, Robert J., Huntly, Brian J. P., Martincorena, Inigo, Anderson, Elizabeth, O’Neill, Laura, Stratton, Michael R., Laurenti, Elisa, Green, Anthony R., Kent, David G., Campbell, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163040/ https://www.ncbi.nlm.nih.gov/pubmed/30185910 http://dx.doi.org/10.1038/s41586-018-0497-0

Ejemplares similares

Development, maturation, and maintenance of human prostate inferred from somatic mutations
por: Grossmann, Sebastian, et al.
Publicado: (2021)

Universal Patterns of Selection in Cancer and Somatic Tissues
por: Martincorena, Iñigo, et al.
Publicado: (2017)

Universal Patterns of Selection in Cancer and Somatic Tissues
por: Martincorena, Iñigo, et al.
Publicado: (2018)

Universal Patterns of Selection in Cancer and Somatic Tissues
por: Martincorena, Iñigo, et al.
Publicado: (2018)

Diverse mutational landscapes in human lymphocytes
por: Machado, Heather E., et al.
Publicado: (2022)

Somatic mutation and clonal expansions in human tissues
por: Martincorena, Inigo
Publicado: (2019)

Somatic Evolution in Non-neoplastic IBD-Affected Colon
por: Olafsson, Sigurgeir, et al.
Publicado: (2020)

Convergent somatic evolution commences in utero in a germline ribosomopathy
por: Machado, Heather E., et al.
Publicado: (2023)

Tobacco exposure and somatic mutations in normal human bronchial epithelium
por: Yoshida, Kenichi, et al.
Publicado: (2020)

Somatic mutations and clonal dynamics in healthy and cirrhotic human liver
por: Brunner, Simon F, et al.
Publicado: (2019)

Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
por: Robinson, Philip S., et al.
Publicado: (2021)

Response to Collinson et al. Comment
por: Belmonte, Miriam, et al.
Publicado: (2020)

Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin
por: Olafsson, Sigurgeir, et al.
Publicado: (2023)

Longitudinal Cytokine Profiling Identifies GRO-α and EGF as Potential Biomarkers of Disease Progression in Essential Thrombocythemia
por: Øbro, Nina F., et al.
Publicado: (2020)

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
por: Robinson, Philip S., et al.
Publicado: (2022)

Recurrent histone mutations in T‐cell acute lymphoblastic leukaemia
por: Collord, Grace, et al.
Publicado: (2018)

Somatic cell gene mutations in humans: biomarkers for genotoxicity.
por: Albertini, R J, et al.
Publicado: (1993)

Clonal dynamics of haematopoiesis across the human lifespan
por: Mitchell, Emily, et al.
Publicado: (2022)

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
por: Bamford, S, et al.
Publicado: (2004)

Flow Sorting, Whole Genome Amplification and Next-Generation Sequencing as Combined Tools to Study Heterogeneous Acute Lymphoblastic Leukemia
por: Fardoos, Rabiah, et al.
Publicado: (2023)

Progression inference for somatic mutations in cancer
por: Peterson, Leif E., et al.
Publicado: (2017)

Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells
por: Rouhani, Foad J., et al.
Publicado: (2022)

Joint genotype inference with germline and somatic mutations
por: Bareke, Eric, et al.
Publicado: (2013)

CNValidator: validating somatic copy-number inference
por: Smith, Lucian P, et al.
Publicado: (2019)

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
por: Forbes, Simon A., et al.
Publicado: (2011)

Somatic mutation rates scale with lifespan across mammals
por: Cagan, Alex, et al.
Publicado: (2022)

Making humans better and making better humans
por: Levitt, Mairi, et al.
Publicado: (2010)

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes()
por: Alexandrov, Ludmil B, et al.
Publicado: (2014)

Data mining using the Catalogue of Somatic Mutations in Cancer BioMart
por: Shepherd, Rebecca, et al.
Publicado: (2011)

Processed pseudogenes acquired somatically during cancer development
por: Cooke, Susanna L., et al.
Publicado: (2014)

Virmid: accurate detection of somatic mutations with sample impurity inference
por: Kim, Sangwoo, et al.
Publicado: (2013)

Somatic mutations reveal asymmetric cellular dynamics in the early human embryo
por: Ju, Young Seok, et al.
Publicado: (2017)

COSMIC: the catalogue of somatic mutations in cancer
por: Bindal, Nidhi, et al.
Publicado: (2011)

Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures
por: Oedekoven, Caroline A., et al.
Publicado: (2021)

Bayesian nonparametric inference for heterogeneously mixing infectious disease models
por: Seymour, Rowland G., et al.
Publicado: (2022)

Somatic structural rearrangements in genetically engineered mouse mammary tumors
por: Varela, Ignacio, et al.
Publicado: (2010)

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
por: Ju, Young Seok, et al.
Publicado: (2014)

Inferring clonal evolution of tumors from single nucleotide somatic mutations
por: Jiao, Wei, et al.
Publicado: (2014)

SomaticSignatures: inferring mutational signatures from single-nucleotide variants
por: Gehring, Julian S., et al.
Publicado: (2015)

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/−) leukemia
por: van der Weyden, Louise, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_63sluivkgb1sp0fme1nekot6p1