Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization

The activation of human bronchial fibroblasts by transforming growth factor-β(1) (TGF-β(1)) leads to the formation of highly contractile myofibroblasts in the process of the fibroblast–myofibroblast transition (FMT). This process is crucial for subepithelial fibrosis and bronchial wall remodeling in...

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Detalles Bibliográficos
Autores principales: Paw, Milena, Wnuk, Dawid, Kądziołka, Dominika, Sęk, Aleksandra, Lasota, Sławomir, Czyż, Jarosław, Madeja, Zbigniew, Michalik, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163263/
https://www.ncbi.nlm.nih.gov/pubmed/30158495
http://dx.doi.org/10.3390/ijms19092571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163263/
https://www.ncbi.nlm.nih.gov/pubmed/30158495
http://dx.doi.org/10.3390/ijms19092571

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