Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities

Right ventricular failure (RVF) remains the leading cause of death in pulmonary arterial hypertension (PAH). We investigated the transcriptomic signature of RVF in hemodynamically well-phenotyped monocrotaline (MCT)-treated, male, Sprague-Dawley rats with severe PAH and decompensated RVF (increased...

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Detalles Bibliográficos
Autores principales: Potus, Francois, Hindmarch, Charles Colin Thomas, Dunham-Snary, Kimberly J., Stafford, Jeff, Archer, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164263/
https://www.ncbi.nlm.nih.gov/pubmed/30213070
http://dx.doi.org/10.3390/ijms19092730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164263/
https://www.ncbi.nlm.nih.gov/pubmed/30213070
http://dx.doi.org/10.3390/ijms19092730

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