Synthesis, Evaluation for Cytotoxicity and Molecular Docking Studies of Benzo[c]furan-Chalcones for Potential to Inhibit Tubulin Polymerization and/or EGFR-Tyrosine Kinase Phosphorylation

A series of 2-arylbenzo[c]furan-chalcone hybrids 3a–y have been synthesized and evaluated for antiproliferative effects against the human breast cancer (MCF-7) cell line and for its potential to induce apoptosis and also to inhibit tubulin polymerization and/or epidermal growth factor receptor-tyros...

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Detalles Bibliográficos
Autores principales: Mphahlele, Malose J., Maluleka, Marole M., Parbhoo, Nishal, Malindisa, Sibusiso T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164331/
https://www.ncbi.nlm.nih.gov/pubmed/30154363
http://dx.doi.org/10.3390/ijms19092552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164331/
https://www.ncbi.nlm.nih.gov/pubmed/30154363
http://dx.doi.org/10.3390/ijms19092552

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