Total Synthesis of Pulmonarin B and Design of Brominated Phenylacetic Acid/Tacrine Hybrids: Marine Pharmacophore Inspired Discovery of New ChE and Aβ Aggregation Inhibitors

A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogues were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay results revealed that 1 showed moderate dual acetylcholinesterase (AChE)/ butyrylcholinesterase (BChE) inhibitory act...

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Detalles Bibliográficos
Autores principales: Cheng, Zhi-Qiang, Song, Jia-Li, Zhu, Kongkai, Zhang, Juan, Jiang, Cheng-Shi, Zhang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164518/
https://www.ncbi.nlm.nih.gov/pubmed/30134630
http://dx.doi.org/10.3390/md16090293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164518/
https://www.ncbi.nlm.nih.gov/pubmed/30134630
http://dx.doi.org/10.3390/md16090293

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