GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling

Huntington’s disease (HD) is a progressive and fatal neurodegenerative disease caused by CAG repeat expansion in the coding region of huntingtin (HTT) protein. The accumulation of mutant HTT (mHTT) contributes to neurotoxicity by causing autophagy defects and oxidative stress that ultimately lead to...

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Detalles Bibliográficos
Autores principales: Chang, Ching-Chi, Lin, Tzu-Chin, Ho, Hsiao-Li, Kuo, Chien-Yin, Li, Hsin-Hua, Korolenko, Tatiana A., Chen, Wei-Jen, Lai, Te-Jen, Ho, Ying-Jui, Lin, Chih-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164932/
https://www.ncbi.nlm.nih.gov/pubmed/30149534
http://dx.doi.org/10.3390/ijms19092505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164932/
https://www.ncbi.nlm.nih.gov/pubmed/30149534
http://dx.doi.org/10.3390/ijms19092505

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