Th1-Biased Immunomodulation and In Vivo Antitumor Effect of a Novel Piperine Analogue

Natural products have an important role as prototypes in the synthesis of new anticancer drugs. Piperine is an alkaloid amide with antitumor activity and significant toxicity. Then, the N-(p-nitrophenyl)acetamide piperinoate (HE-02) was synthesized, and tested for toxicological and antitumor effects...

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Detalles Bibliográficos
Autores principales: Santos, Jephesson, Brito, Monalisa, Ferreira, Rafael, Moura, Ana Paula, Sousa, Tatyanna, Batista, Tatianne, Mangueira, Vivianne, Leite, Fagner, Cruz, Ryldene, Vieira, Giciane, Lira, Bruno, Athayde-Filho, Petrônio, Souza, Helivaldo, Costa, Normando, Veras, Robson, Barbosa-Filho, José Maria, Magalhães, Hemerson, Sobral, Marianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165130/
https://www.ncbi.nlm.nih.gov/pubmed/30200386
http://dx.doi.org/10.3390/ijms19092594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165130/
https://www.ncbi.nlm.nih.gov/pubmed/30200386
http://dx.doi.org/10.3390/ijms19092594

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