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Th1-Biased Immunomodulation and In Vivo Antitumor Effect of a Novel Piperine Analogue
Natural products have an important role as prototypes in the synthesis of new anticancer drugs. Piperine is an alkaloid amide with antitumor activity and significant toxicity. Then, the N-(p-nitrophenyl)acetamide piperinoate (HE-02) was synthesized, and tested for toxicological and antitumor effects...
Autores principales: | Santos, Jephesson, Brito, Monalisa, Ferreira, Rafael, Moura, Ana Paula, Sousa, Tatyanna, Batista, Tatianne, Mangueira, Vivianne, Leite, Fagner, Cruz, Ryldene, Vieira, Giciane, Lira, Bruno, Athayde-Filho, Petrônio, Souza, Helivaldo, Costa, Normando, Veras, Robson, Barbosa-Filho, José Maria, Magalhães, Hemerson, Sobral, Marianna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165130/ https://www.ncbi.nlm.nih.gov/pubmed/30200386 http://dx.doi.org/10.3390/ijms19092594 |
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