Identification of an Essential Cytoplasmic Region of Interleukin-7 Receptor α Subunit in B-Cell Development

Interleukin-7 (IL-7) is essential for lymphocyte development. To identify the functional subdomains in the cytoplasmic tail of the IL-7 receptor (IL-7R) α chain, here, we constructed a series of IL-7Rα deletion mutants. We found that IL-7Rα-deficient hematopoietic progenitor cells (HPCs) gave rise t...

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Detalles Bibliográficos
Autores principales: Kasai, Hirotake, Kuwabara, Taku, Matsui, Yukihide, Nakajima, Koichi, Kondo, Motonari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165445/
https://www.ncbi.nlm.nih.gov/pubmed/30149646
http://dx.doi.org/10.3390/ijms19092522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165445/
https://www.ncbi.nlm.nih.gov/pubmed/30149646
http://dx.doi.org/10.3390/ijms19092522

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