Covalent Rpn13-Binding Inhibitors for the Treatment of Ovarian Cancer

[Image: see text] Substitution of the m,p-chloro groups of bis-benzylidinepiperidone RA190 for p-nitro, generating RA183, enhanced covalent drug binding to Cys88 of RPN13. Treatment of cancer cell lines with RA183 inhibited ubiquitin-mediated protein degradation, resulting in rapid accumulation of h...

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Detalles Bibliográficos
Autores principales: Anchoori, Ravi K., Jiang, Rosie, Peng, Shiwen, Soong, Ruey-shyang, Algethami, Aliyah, Rudek, Michelle A., Anders, Nicole, Hung, Chien-Fu, Chen, Xiang, Lu, Xiuxiu, Kayode, Olumide, Dyba, Marzena, Walters, Kylie J., Roden, Richard B. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166221/
https://www.ncbi.nlm.nih.gov/pubmed/30288466
http://dx.doi.org/10.1021/acsomega.8b01479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166221/
https://www.ncbi.nlm.nih.gov/pubmed/30288466
http://dx.doi.org/10.1021/acsomega.8b01479

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