Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels

Human Mpv17-like protein (M-LPH) has been suggested to participate in prevention of mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) damage. To clarify the molecular mechanism of M-LPH function, we knocked out M-LPH in human hepatoma HepG2 using CRISPR-Cas9 technology. An increase in mt...

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Detalles Bibliográficos
Autores principales: Iida, Reiko, Ueki, Misuzu, Yasuda, Toshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166373/
https://www.ncbi.nlm.nih.gov/pubmed/30310528
http://dx.doi.org/10.1155/2018/6956414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166373/
https://www.ncbi.nlm.nih.gov/pubmed/30310528
http://dx.doi.org/10.1155/2018/6956414

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