An intronic genetic variation of MGMT affects enhancer activity and is associated with glioma susceptibility

PURPOSE: O(6)-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in repairing damaged DNA caused by alkylating agents. A number of cancer susceptibility loci have been recognized as enhancer variants. This study aimed to explore the significance of enhancer variants of MGMT in glioma su...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Liming, Xu, Wenshen, Dai, Lian, Yan, Danfang, Zhang, Shu, Shi, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166748/
https://www.ncbi.nlm.nih.gov/pubmed/30310321
http://dx.doi.org/10.2147/CMAR.S176622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166748/
https://www.ncbi.nlm.nih.gov/pubmed/30310321
http://dx.doi.org/10.2147/CMAR.S176622

Ejemplares similares