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An intronic genetic variation of MGMT affects enhancer activity and is associated with glioma susceptibility

PURPOSE: O(6)-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in repairing damaged DNA caused by alkylating agents. A number of cancer susceptibility loci have been recognized as enhancer variants. This study aimed to explore the significance of enhancer variants of MGMT in glioma su...

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Detalles Bibliográficos
Autores principales:	Huang, Liming, Xu, Wenshen, Dai, Lian, Yan, Danfang, Zhang, Shu, Shi, Xi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166748/ https://www.ncbi.nlm.nih.gov/pubmed/30310321 http://dx.doi.org/10.2147/CMAR.S176622

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