LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

Leucine-rich repeat kinase 2 (LRRK2) has been associated with a variety of human diseases, including Parkinson’s disease and Crohn’s disease, whereas LRRK2 deficiency leads to accumulation of abnormal lysosomes in aged animals. However, the cellular roles and mechanisms of LRRK2-mediated lysosomal r...

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Detalles Bibliográficos
Autores principales: Eguchi, Tomoya, Kuwahara, Tomoki, Sakurai, Maria, Komori, Tadayuki, Fujimoto, Tetta, Ito, Genta, Yoshimura, Shin-ichiro, Harada, Akihiro, Fukuda, Mitsunori, Koike, Masato, Iwatsubo, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166828/
https://www.ncbi.nlm.nih.gov/pubmed/30209220
http://dx.doi.org/10.1073/pnas.1812196115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166828/
https://www.ncbi.nlm.nih.gov/pubmed/30209220
http://dx.doi.org/10.1073/pnas.1812196115

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